Metagenomi products

Ultra-small nucleases to expand in vivo delivery options; Our ultra-small nucle­as­es are high­ly effi­cient genome edit­ing sys­tems that have the poten­tial for exten­sive ther­a­peu­tic appli­ca­tions. We have pri­or­i­tized find­ing sys­tems to over­come the size con­straints of first gen­er­a­tion nucle­as­es. Our sys­tems are a frac­tion of the size and pack­age eas­i­ly into a sin­gle AAV for tar­get­ing organs beyond what is pos­si­ble with lipid nanopar­ti­cle delivery.

Genomic replacements and insertions; Metageno­mi’s RIGS make pro­gram­ma­ble genom­ic mod­i­fi­ca­tions that are encod­ed in RNA tem­plates. Using RIGS we can achieve small edits (prime edit­ing), as well as large edits. Our RIGS plat­form allows us to address more com­plex gene edits such as inser­tions, dele­tions, and all types of point mutations.