NanoPin Technologies Inc. products

To address these issues, NanoPin uses an antibody enrichment approach to capture species-specific biomarker peptides released upon trypsin digestion of the serum of infected individuals and employs mass spectrometry to identify these peptides with high sensitivity and accuracy. This approach has several advantages, since serum digestion cleaves all factors that may interact with a biomarker target to remove their masking effect and increase the amount of target protein available for analysis, while pathogen-derived peptides biomarker peptides produced during this digestion can be used to uniquely distinguish highly conserved proteins expressed by closely related pathogens. Finally, antibody-mediated enrichment of a target peptides prior to their analysis by tandem mass spectrometry serves to increase both the sensitivity and specificity of their detection.