Newcells Biotech Limited services

In vitro assessment of Fibroblast-to-Myofibroblast transition (FMT). Newcells offers a fast and reliable FMT assay service to evaluate the efficacy of anti-fibrotic compounds using high-content imaging. This customisable, high-throughput assay is well suited to compound screening for small molecules targeting lung fibrosis. Normal repair processes are defective in the fibrotic lung. Repetitive cellular microinjuries and a heightened immune response leads to chronic activation of fibroblasts. Activated fibroblasts differentiate into myofibroblasts, a process known as fibroblast-to-myofibroblast transition (FMT). This persistent myofibroblast phenotype leads to an increased synthesis of extracellular matrix proteins, and their deposition within the lung parenchyma, causing progressive scarring, increased lung stiffness and a loss in lung function.