Nuvonis services

The generation of high titer vaccines with acceptable purity is a challenging task, both regarding upstream and downstream steps. Upstream development uses well established technologies such as bioreactors (e.g., single use) or high-cell density systems based on microcarrier technology. An integral part of process development is the fine funing between cell substrate, virus parameters and growth conditions with the goal to achieve high product titers. The general approach in downstream development is to use a sequence of unit operations such as column chromatography, ultracentrifugation and/or ultrafiltration. Therefore, a simple and efficient sequence of steps can increase product yield and quality.