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Origin - Nitric Oxide Technology
Nitric Oxide (NO) was first prepared in 1620 and first studied in 1720. It was poorly understood until the late 1900s. The discovery of the role of NO as fundamental to biologic function was so remarkable that hundreds of research papers led Nitric Oxide to be proclaimed "molecule of the year" in 1992 by the journal Science. Three NO researchers shared the 1998 Nobel Prize in Physiology or Medicine for their discovery that what had previously been known as EDRF (endothelium-derived relaxing factor) was, in fact, NO (13,14).
