articles

Schistosomiasis is a major neglected tropical disease (NTD) of public health concern to a billion people. Currently an estimated 200 million are infected and an additional an estimated 800 million people are at risk of acquiring this disease in 74 countries. The disease carries high morbidity. Revised estimates of disability adjusted life years (DALYs) and recent calculations based on health-related quality of life (HrQoL) points to a much higher disease burden of schistosomiasis than has pre

Tuberculosis - a deadly disease with a huge global burden

Tuberculosis continues to be the most serious cause of death from a single infectious micro-organism. Drug resistant tuberculosis is a particularly insidious manifestation of this disease for which alternative approaches to conventional therapy are required to facilitate treatment.  Despite heroic efforts to develop new drugs to treat tuberculosis a very small number are currently in late stage development

The World Health Organization in its report on Neglected Tropical Diseases has stated that there is overwhelming evidence to show that the burden caused by many of the 17 diseases that affect more than 1 billion people worldwide can be effectively controlled and, in many cases, eliminated or even eradicated. Leishmaniasis caused by Leishmania spp is one such example and poses a grave health risk to an estimated 350 million people. Between 200,000 and 400,000 cases of visceral leishma

PAI has access to a complete chemistry laboratory facility through a service agreement with the Infectious Disease Research Institute located in the same building. In addition to fume hoods, rotary evaporators, and glassware, we are able to use major equipment including a Bruker Avance 300 MHz NMR spectrometer, Agilent 1100 LCMS, preparative HPLC systems, automatic flash chromatography system, hydrogenator, and ozone generator.