ProImmune Ltd. products

Human MR1 Tetramers detect MAIT cells with human MR1 tetramers. ProImmune is the leading commercial source worldwide for fluorescently labeled human MR1 tetramers. MR1 complexes bind to T cell receptors on mucosal-associated invariant T (MAIT) cells. MAIT cells have a particular specificity (as determined by the relevant MR1-binding small molecule ligand used), allowing identification, enumeration and isolation of antigen-specific MAIT cells by flow cytometry. Our tetramers show excellent brightness and experimental reproducibility. To avoid the difficulties associated with dissolving and loading the most commonly used ligands, 5-OP-RU and 6-FP, our tetramers come pre-loaded (not available in Australia and the United States). They can also be supplied empty for loading with your ligand of choice.

ProM2® MHC Class II Monomers, biotinylated enabling specialist assays for defined MHC Class II peptide target  interactions. Best in class MHC Class II Monomers: ProM2® Class II MHC Monomers are pre-biotinylated and can be readily adapted either to detect and separate single-antigen specific T cells or implement specialist solid or solution phase immunoassays for measuring interactions of predefined MHC Class II-peptide complexes with ligands such as monoclonal antibodies, recombinant T cell receptors, or other binding scaffolds, e.g. for use in screening of novel antigen-specific CAR T cell antigen receptors.

CD1d Tetramers the world’s leading product for tracking NKT cells. Detect NKT Cells with CD1d Tetramers: ProImmune is the leading commercial source worldwide for fluorescently labeled human and mouse CD1d tetramers. CD1d-lipid complexes bind to T cell receptors of NKT cells of a particular specificity (as determined by the lipid ligand used), allowing identification and enumeration of antigen-specific CD1d-restricted NKT cells by flow cytometry. Our tetramers show excellent brightness and experimental reproducibility. To avoid the difficulties associated with dissolving and loading the most commonly used ligand, alpha-Galactosyl Ceramide* (α-GalCer), our tetramers come pre-loaded. They can also be supplied empty for loading with your ligand of choice.

ProMix™ Peptide Pools purified immunodominant epitope peptide pools for precise monitoring of functional T cell responses.

ProT2® MHC Class II Tetramers track antigen-specific CD4+ T cells with the most comprehensive class II tetramer catalog range now also available for H-2 IAb, IAd, IAg7.