Sensidose AB articles

This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson`s disease, have been developed in collaborative research within departments at Uppsala University.

During its almost half-century of use for treating Parkinson`s disease, levodopa therapy has permitted most patients to reverse much of this disorder`s symptomatology. However, the full range of its therapeutic properties is not completely understood, as levodopa is showing itself to be more than just a metabolic intermediate for dopamine synthesis. Improving the constancy of drug delivery is the next frontier for enhancing therapeutic options with lev

This review describes the different drug delivery systems containing levodopa that are used in the treatment of Parkinson`s disease. Their composition, process of preparation, advantages, disadvantages and limitations are discussed as well as the major objective in the management of Parkinson`s disease according to the pathology of the disease.

Levodopa serves as the gold standard of anti-parkinsonian therapy and nearly every patient with Parkinson`s disease eventually receives this drug. To improve upon levodopa therapy, several forms of treatment have been devised to augment its actions, and new delivery systems are under development. This new research offers promise for improving outcomes with this highly effective therapy.

Physicians modify drug schedules in response to their patients` clinical responses. Failure to relieve patients` symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor medication use, nonadherence of drug use was examined in subjects with Pa