Solvias AG
3 services found

Solvias AG services

Polymorphism, Salts & Crystallization

Solid-State Development Service

The majority of drugs are administered as solids. This means that apart from the molecular structure of the active ingredient, solid-state properties significantly influence the performance of the final product. New substances with pharmaceutical activity are often weak acids or bases or may have unsuitable solid-state properties. In such cases, it may be preferable to develop the drug as a salt or co-crystal form.

Crystallization Screening Services

Most drug substances are marketed as crystalline material. Having a crystalline drug candidate is beneficial to development processes and simplifies registration. We offer crystallization screening services and also complete crystallization development programs.

Single Parameters and Specialties

Preformulation Package: Preformulation includes the compiling of solubility profiles (pH dependent and other systems of interest), permeability (logP/D, CaCo2 or other cell-based assays), BCS classification, accelerated chemical stability, basic physico-chemical parameters like pKa, melting point, hygroscopicity, salt screening, and polymorphism screening.