D-TEK - Model M2/nPDC - Antibodies - Brochure

The M2 antibodies belong to the group of Anti-Mitochondrial Antibodies (AMA) and are strongly associated with PBC. At least 9 distinct AMA have been identified, which have been classified M1-M9 according to their antigen specificity and disease association. Of these, only the M2 subtype approaches absolute specificity for PBC. Indeed, about 95 % of PBC patients have M2 autoantibodies and, conversely, about 90 % of asymptomatic individuals who are found to be M2-positive on routine screening can be shown to have underlying PBC on further investigation.