In implant dentistry, our heritage is truly unique. A philosophy of innovation, driven by patient need. A company inspired and led – to this day – by dental professionals who began their own journeys in practices and laboratories.

This all stems from Per-Ingvar Brånemark’s groundbreaking discovery of osseointegration. The sequence of companies that grew after he treated the very first patient, culminated in Nobel Biocare.

1952 - Brånemark discovers osseointegration

In the 1950s as a young researcher, Per-Ingvar Brånemark was completely absorbed in the study of the anatomy of blood flow.

As part of that work, he attached a titanium-housed optical component to a rabbit’s leg, which made it possible to study microcirculation in the bone tissue through specially modified microscopes.

The work at hand was completed successfully, but when it came time to remove the metal-framed optics from the bone, he famously discovered that the bone and titanium had become virtually inseparable.

“Not long afterwards,” Brånemark said, “we changed the direction of our work to investigate the body’s ability to tolerate titanium.”

1965 - First titanium implant

In 1965, Gösta Larsson of Gothenburg, Sweden, was an oral invalid. The very first osseointegrated dental implants, carefully placed by Professor Per-Ingvar Brånemark dramatically changed his life.

After extensive clinical trials and years of additional research, Per-Ingvar Brånemark and the Swedish company Bofors went on to found Nobelpharma, which later became Nobel Biocare.

1981 - Nobelpharma is founded in Gothenburg, Sweden 1988 - First zygomatic implants

In 1988 Prof. Brånemark introduced zygomatic implants designed to rehabilitate the upper maxilla when severely resorbed. The Brånemark System Zygoma implants anchor in the zygomatic bone, which avoids complex bone-grafting procedures.¹

1989 - First ceramic CAD/CAM coping

Dr. Matts Andersson brought the next leap in function and esthetics for dental prosthetics: the first ceramic CAD/CAM coping.

1996 - Nobelpharma becomes Nobel Biocare 1997 - First tapered implant

Replace was the first tapered dental implant, mimicking the shape of a natural tooth root. Replace Select and NobelReplace Tapered went on to become the world’s most frequently used implant system.

1998 - First tilted and immediate implant solution: All-on-4® treatment concept

In collaboration with Dr. Paulo Maló, we created a concept with tilted and immediately loaded implants – the first of its kind. The legendary All-on-4® treatment concept.

2000 - TiUnite improves treatment outcomes

The moderately rough, anodized surface for osseointegration, TiUnite, has built a reputation for success and is one of the most clinically researched implant surfaces in the world.²

2005 - Immediate Function receives FDA clearance

Immediate Function received clearance by the U.S. Food and Drug Administration (FDA) – at the time, this was unique only to Nobel Biocare.

2005 - First guided surgery system

In 2005, NobelGuide digitized dental implantology by introducing the first comprehensive concept for 3D treatment planning and guided surgery.

2008 - NobelActive is released

NobelActive can allow for Immediate Function in cases where it might otherwise be impossible. To this day, it is still often copied, but never equaled.^3-6

2015 - Nobel Biocare is acquired by the Danaher corporation, a global science and technology innovator. 2019 - The Mucointegration™ era arrives with Xeal™ and TiUltra™

P-I Brånemark made implant dentistry possible with his discovery of osseointegration. With the launch of Xeal™ and TiUltra™ at the IDS in Cologne we go beyond osseointegration to surfaces specifically created for soft tissue attachment as well.^7,8

2020 - Reshaping implantology with N1™ implant system

Direct – Shape – Place: the Nobel Biocare N1™ implant system is a landmark innovation created to empower clinicians with simplicity and confidence, for greater patient comfort. It is a complete system featuring new concepts in site preparation, implant macroshape, prosthetic connections, emergence profile and more. ^9,10

Xeal and TiUltra - Surfaces System - Brochure