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MedChemExpressModel Ondansetron hydrochloride dihydrate -103639-04-9

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Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery[1][2].
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Ondansetron hydrochloride dihydrate

MCE China:Ondansetron hydrochloride dihydrate

Brand:MedChemExpress (MCE)

Cat. No.HY-B0002A

CAS:103639-04-9

Synonyms:GR 38032 hydrochloride dihydrate; SN 307 hydrochloride dihydrate

Purity:99.94%

Storage:4°C, sealed storage, away from moisture and light *The compound is unstable in solutions, freshly prepared is recommended.

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery.

In Vivo:Ondansetron hydrochloride dehydrate (2 mg/kg; i.p.; single) blocks radiation sickness when combines with Dexamethasone (2 mg/kg) and CP-99,994 (15 mg/kg), in radiation-induced pica model[1].

IC50 & Target:5-HT3 Receptor

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References:

[1]. Yamamoto K, et al. Ondansetron, dexamethasone and an NK1 antagonist block radiation sickness in mice. Pharmacol Biochem Behav. 2005 Sep;82(1):24-9.  [Content Brief]

[2]. Wilde MI, et al. Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications. Drugs. 1996 Nov;52(5):773-94.  [Content Brief]

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