MedChemExpress - Model Anethole -104-46-1
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer[1][2][3][4][5].MCE products for research use only. We do not sell to patients.
Anethole
MCE China：Anethole
Brand：MedChemExpress (MCE)
Cat. No.HY-B0900
CAS：104-46-1
Synonyms：Anise camphor; p-Propenylanisole; Isoestragole
Purity：99.61%
Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer.
In Vitro：Anethole (0.5-1 μM; 1 h) can inhibit H2O2 (300 Μm; 24 h)-induced apoptosis and viability loss in human skin fibroblasts CRL1474[2]. Anethole has synergistic effects on the antifungal activities of phytochemicals including polygodial and 2E-undecenal against Saccharomyces cerevisiae and Candida albicans[3].
In Vivo：Anethole (62.5-500 mg/kg; Intraperitoneal injection, single dose) has an anti-inflammatory effect in BALB/C mice induced by LPS (1.5 mg/kg) (HY-D1056)[4]. Anethole (250-1000 mg/kg; P.O.; Once every other day for 60 consecutive days) has anti-tumor effects in Ehrlich ascites tumor Swiss albino mice[5].
IC50 & Target：MMP-9
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References：
[1]. Freire R S, et al. Synthesis and antioxidant, anti-inflammatory and gastroprotector activities of anethole and related compounds[J]. Bioorganic & medicinal chemistry, 2005, 13(13): 4353-4358. [Content Brief]
[2]. Galicka A, Krętowski R, Nazaruk J, et al. Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblasts[J]. Molecular and Cellular Biochemistry, 2014, 394: 217-224. [Content Brief]
[3]. Fujita K, et al. Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent[J]. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2007, 21(1): 47-51. [Content Brief]
[4]. Kang P, et al. Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice[J]. Life sciences, 2013, 93(24): 955-961. [Content Brief]
[5]. Al-Harbi M M, et al. Influence of anethole treatment on the tumour induced by Ehrlich ascites carcinoma cells in paw of Swiss albino mice[J]. European Journal of Cancer Prevention, 1995, 4(4): 307-318. [Content Brief]
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