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Plantamajoside

MCE China：Plantamajoside

Brand：MedChemExpress (MCE)

Cat. No.HY-N0031

CAS：104777-68-6

Purity：99.52%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects.

In Vitro：Plantamajoside (1-800 µg/mL, 24 h-2 weeks) inhibits proliferation, stemness, and migration, and initiates apoptosis in 95D cells and dose-dependently suppresses the survival of 95D cells[3]. Plantamajoside (10 µM, 1-24 h) from Plantago asiatica modulates human umbilical vein endothelial cell dysfunction by glyceraldehyde-induced AGEs via MAPK/NF-κB[4]. Plantamajoside (10-40 µM, 24 h) inhibits high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in rat glomerular mesangial cells HBZY-1 through the inactivation of Akt/NF-κB pathway[5]. Plantamajoside (5-120 µM 48 h) alleviates hypoxia-reoxygenation injury through integrin-linked kinase/c-Src/Akt and the mitochondrial apoptosis signaling pathways in H9c2 myocardial cells[6]. Plantamajoside (10-20 µM, 12-48 h) inhibits hypoxia-induced migration and invasion of human cervical cancer cells (SiHa and CaSki) through blocking the NF-κB and PI3K/akt pathways[7]. Plantamajoside (20-320 μg/mL, 24 h) ameliorates TGFβ2-induced autophagy, epithelial–mesenchymal transition and inflammatory processes in human lens epithelial cells (hLECs)[8]. Plantamajoside (20-160 μg/mL, 48 h) inhibits proliferation, migration, invasion and induces apoptosis in activated HSC-T6 cell[9]. Plantamajoside (20-160 μg/mL, 24-72 h) inhibits the invasion, migration and viability of malignant melanoma cells A2058[10]. Plantamajoside (2.5-40 μg/mL, 7 days) promotes metformin-induced apoptosis, autophagy and proliferation arrest of liver cancer cells via suppressing Akt/GSK3β signaling[11]. Plantamajoside (31.25-500 μg/mL, 12-48 h) inhibits breast cancer cells (MDA-MB-231) growth by decreasing the activity of matrix metalloproteinase-9 and -2[12]. Plantamajoside (10-80 μM, 24 h) protects H9c2 cells against hypoxia/reoxygenation-induced injury through regulating the akt/Nrf2/HO-1 and NF-κB signaling pathways[13]. Plantamajoside (20-160 g/mL) inhibits HCC cells progression through regulating cell viability, apoptosis, migration, invasion and PI3K/AKT pathway[14].

In Vivo：Plantamajoside (20-80 mg/kg) promotes the recovery of neurological function and protects the tissue structure of the spinal cord after ASCI in a rat model of acute spinal cord injury[15]. Plantamajoside (25-100 mg/kg, i.p., 24 h) alleviates acute sepsis-induced organ dysfunction through inhibiting the TRAF6/NF-κB axis in mice[16]. Plantamajoside (10-40 mg/kg, p.o., 4 weeks) has protective activities against Cd-induced renal injury in rats[17]. Plantamajoside (25-100 mg/kg, i.p., three times at 6, 12, 18 h) ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation in mice[18]. Plantamajoside (20-80 mg/kg, i.p., once a day for 4 weeks) modulates immune dysregulation and hepatic lipid metabolism in rats with nonalcoholic fatty liver disease via AMPK/Nrf2 elevation[19].

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References：

[1]. Wu H, et al. Plantamajoside ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation.Int Immunopharmacol. 2016 Jun;35:315-322.  [Content Brief]

[2]. Zuo X, Li L, Sun L. Plantamajoside inhibits hypoxia-induced migration and invasion of human cervical cancer cells through the NF-κB and PI3K/akt pathways. J Recept Signal Transduct Res. 2021;41(4):339-348.  [Content Brief]

[3]. Li Y, et al. Plantamajoside modulates the proliferation, stemness, and apoptosis of lung carcinoma via restraining p38MAPK and AKT phosphorylation. Transl Cancer Res. 2020 Jun;9(6):3828-3841.  [Content Brief]

[4]. Son WR, et al. Plantamajoside from Plantago asiatica modulates human umbilical vein endothelial cell dysfunction by glyceraldehyde-induced AGEs via MAPK/NF-κB. BMC Complement Altern Med. 2017 Jan 21;17(1):66.  [Content Brief]

[5]. Xiao D, et al. Plantamajoside inhibits high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in rat glomerular mesangial cells through the inactivation of Akt/NF-κB pathway. J Recept Signal Transduct Res. 2021 Feb;41(1):45-52.  [Content Brief]

[6]. Du Y, et al. Plantamajoside alleviates hypoxia-reoxygenation injury through integrin-linked kinase/c-Src/Akt and the mitochondrial apoptosis signaling pathways in H9c2 myocardial cells. BMC Complement Med Ther. 2023 Feb 24;23(1):64.  [Content Brief]

[7]. Zuo X, et al. Plantamajoside inhibits hypoxia-induced migration and invasion of human cervical cancer cells through the NF-κB and PI3K/akt pathways. J Recept Signal Transduct Res. 2021 Aug;41(4):339-348.  [Content Brief]

[8]. Sun X, et al. Plantamajoside ameliorates TGFβ2-induced autophagy, epithelial–mesenchymal transition and inflammatory processes in human lens epithelial cells. Molecular & Cellular Toxicology, 2024: 1-9.

[9]. Wang Y, et al. Plantamajoside exerts antifibrosis effects in the liver by inhibiting hepatic stellate cell activation. Exp Ther Med. 2019 Oct;18(4):2421-2428.  [Content Brief]

[10]. Wang Y, et al. Plantamajoside represses the growth and metastasis of malignant melanoma. Exp Ther Med. 2020 Mar;19(3):2296-2302.  [Content Brief]

[11]. Wang Z, et al. Plantamajoside promotes metformin-induced apoptosis, autophagy and proliferation arrest of liver cancer cells via suppressing Akt/GSK3β signaling. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221078868.  [Content Brief]

[12]. Pei S, et al. Plantamajoside, a potential anti-tumor herbal medicine inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of matrix metalloproteinase-9 and -2. BMC Cancer. 2015 Dec 16;15:965.  [Content Brief]

[13]. Zeng G, et al. Plantamajoside protects H9c2 cells against hypoxia/reoxygenation-induced injury through regulating the akt/Nrf2/HO-1 and NF-κB signaling pathways. J Recept Signal Transduct Res. 2022 Apr;42(2):125-132.  [Content Brief]

[14]. Zhou, Yiqun, et al. Plantamajoside Inhibits Hepatic Carcinoma Cell Proliferation, Migration, Invasion and Induces Apoptosis Through Regulating Phosphatidylinositol-3-Kinase/ Protein Kinase B Pathway. Journal of Biomaterials and Tissue Engineering, Volume 10, Number 5, May 2020, pp. 662-668(7).

[15]. Hu H, et al. The protective mechanism of action of plantamajoside on a rat model of acute spinal cord injury. Exp Ther Med. 2021 Apr;21(4):378.  [Content Brief]

[16]. Feng D, et al. Plantamajoside alleviates acute sepsis-induced organ dysfunction through inhibiting the TRAF6/NF-κB axis. Pharm Biol. 2023 Dec;61(1):897-906.  [Content Brief]

[17]. Jung HY, et al. Nephroprotection of plantamajoside in rats treated with cadmium. Environ Toxicol Pharmacol. 2015 Jan;39(1):125-36.  [Content Brief]

[18]. Wu H, et al. Plantamajoside ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation. Int Immunopharmacol. 2016 Jun;35:315-322.  [Content Brief]

[19]. Wu JM, et al. Plantamajoside modulates immune dysregulation and hepatic lipid metabolism in rats with nonalcoholic fatty liver disease via AMPK/Nrf2 elevation. Kaohsiung J Med Sci. 2023 Aug;39(8):801-810.  [Content Brief]