MedChemExpress - Model Dendrophenol -108853-14-1
Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification[1][2][3][4].MCE products for research use only. We do not sell to patients.
Dendrophenol
MCE China：Dendrophenol
Brand：MedChemExpress (MCE)
Cat. No.HY-N6031
CAS：108853-14-1
Synonyms：Moscatilin
Purity：99.93%
Storage：-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification.
In Vitro：Dendrophenol (5-100 μM; 1 h) inhibits the expression of COX-2, iNOS, HIF-1α and NF-κB and inhibits cell activation in LPS (HY-D1056) treated macrophages[1]. Dendrophenol (0-50 μM; 15 h-6 days) exerts potent cytotoxic effect against tumor cell lines from placenta, lung and stomach, and can cause cell G2 phase arrest[2]. Dendrophenol (1 μM; 4 days) reduces calcium deposition via the WNT3/β-catenin pathway and reduces calcification induced inflammation by IL13RA2 and STAT3 in Phosphate-treated human aortic smooth muscle cells[3]. Dendrophenol (3-30 μM; 24 h) induces apoptosis of human colon cancer cell HCT-116 by tubulin depolymerization, DNA damage stress and JNK signaling pathway[4].
In Vivo：Dendrophenol (10 mg/kg; intraperitoneal injection; 3 weeks) has a beneficial effect in the mouse model of vascular calcification[3]. Dendrophenol (50-100 mg/kg; intraperitoneal injection; 5 times a week for 2 weeks) has antitumor effect in mouse tumor model[4].
IC50 & Target：NF-κB COX-2 HIF-1α
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References：
[1]. Liu YN, et al. Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells. Shock. 2010 Jan;33(1):70-5. [Content Brief]
[2]. Ho CK, et al. Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent. Cancer Invest. 2003;21(5):729-36. [Content Brief]
[3]. Zhang T, et al. Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway. J Adv Res. 2024 Mar 2:S2090-1232(24)00082-1. [Content Brief]
[4]. Chen TH, et al. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res. 2008 Jul 1;14(13):4250-8. [Content Brief]
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