- Home
- Companies
- MedChemExpress LLC (MCE)
- Products
- MedChemExpress - Model Urolithin B - ...
MedChemExpress - Model Urolithin B -1139-83-9
Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality[1][2][3][4].MCE products for research use only. We do not sell to patients.
Urolithin B
MCE China：Urolithin B
Brand：MedChemExpress (MCE)
Cat. No.HY-126307
CAS：1139-83-9
Purity：99.85%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality.
In Vitro：Urolithin B (30-100 μM; 24 h) shows anti-inflammatory effects in LPS-stimulated BV2 microglia by modulating pro- and anti-inflammatory molecule. Such like that suppressing NF-κB and AP-1 signaling in LPS-stimulated BV2 cells, and also upregulating AMPK and downregulating the Akt, JNK, and ERK signaling pathway[1].Urolithin B (15 μM; 24 h) enhances the growth and differentiation of C2C12 muscle ducts by increasing protein synthesis and inhibiting the ubiquitin-proteasome pathway[2].
In Vivo：Urolithin B (50 mg/kg; ip; once daily for 4 days) inhibits microglial activation in LPS-injected mouse brains, under neuroinflammatory condition[1].Urolithin B (10 μg/day; mini-osmotic pump delivery, 28 days) induces muscle hypertrophy and reduces muscle atrophy after sciatic nerve transection in mice[2].
IC50 & Target：Human Endogenous Metabolite
Hot selling product：URMC-099 | Stachydrine | Valrubicin | Cenisertib | Oil Red O | GMQ | Filanesib | Ganoderal A | BEBT-908 | AG-09/1
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References：
[1]. Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57. [Content Brief]
[2]. Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597. [Content Brief]
[3]. Lv MY, et al. Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β-catenin signaling. J Cell Biochem. 2019 Oct;120(10):17273-17282. [Content Brief]
[4]. Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。