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MedChemExpress - Model Tranexamic acid -1197-18-8

Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis [1][2][3][4][5].

Tranexamic acid

MCE China：Tranexamic acid

Brand：MedChemExpress (MCE)

Cat. No.HY-B0149

CAS：1197-18-8

Synonyms：cyclocapron

Purity：98.0%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .

In Vitro：Tranexamic acid (20-100 μg/mL, 24 h) attenuates the effects of severe trauma by enhancing mitochondrial respiration, suppressing damage-associated molecular patterns (DAMPs) release and improving capillary integrity in human umbilical vein endothelial cells (HUVECs) and human arterial endothelial cells (HAECs)[1]. Tranexamic acid (0.2-5 mM, 30 min) inhibits cell migration of MDA-MB-231 BAG breast cancer cells[2].

In Vivo：Tranexamic acid (100 mg/kg, Intravenous injection, twice a day for 3-28 days) facilitates a more robust immune activation after traumatic brain injury in plasminogen-deficient mice[3]. Tranexamic acid (750 mg/kg, Oral, once a day for 20 consecutive days) decreases the proliferation of mast cells and increases the proliferation of fibroblasts, subsequently improving wrinkles caused by skin dryness in mice[4].

IC50 & Target：MMP-1

References：

[1]. Prudovsky I, et al. Tranexamic acid suppresses the release of mitochondrial DNA, protects the endothelial monolayer and enhances oxidative phosphorylation [J]. Journal of cellular physiology, 2019, 234(11): 19121-19129. [Content Brief]

[2]. Wu G, et al. Tranexamic acid is an active site inhibitor of urokinase plasminogen activator [J]. Blood advances, 2019, 3(5): 729-733. [Content Brief]

[3]. Draxler D F, et al. Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis [J]. Journal of Thrombosis and Haemostasis, 2019, 17(12): 2174-2187. [Content Brief]

[4]. Hiramoto K, et al. The amelioration effect of tranexamic acid in wrinkles induced by skin dryness [J]. Biomedicine & Pharmacotherapy, 2016, 80: 16-22. [Content Brief]

[5]. Sindet-Pedersen S, et al. Hemostatic effect of tranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery [J]. New England Journal of Medicine, 1989, 320(13): 840-843. [Content Brief]

Brand introduction:
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•   The biological activity of the products has been verified by the experiments of customers in various countries；
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MedChemExpress - Model Tranexamic acid -1197-18-8

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Tranexamic acid