MedChemExpress - Model DSPE-PEG-Folate, MW 3350 -1236288-25-7
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research[1][2][3].MCE products for research use only. We do not sell to patients.
DSPE-PEG-Folate, MW 3350
MCE China：DSPE-PEG-Folate, MW 3350
Brand：MedChemExpress (MCE)
Cat. No.HY-144009
CAS：1236288-25-7
Purity：95.16%
Storage：Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research.
In Vitro：Nanoparticles constructed with DSPE-PEG-Folate and anticancer drugs enter cells mainly through the endocytosis pathway mediated by FA receptors. The nanoparticles mainly accumulate in the cytoplasm, while the released drugs are distributed in the cytoplasm and nucleus, which can effectively deliver drugs to the nucleus to play a role. DSPE-PEG-Folate can increase the elimination half-life of the drug and prolong the blood circulation time[1].
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References：
[1]. Li Y, et, al. Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release. ACS Appl Mater Interfaces. 2015 Aug 19;7(32):17573-81. [Content Brief]
[2]. Werner ME, et, al. Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials. 2011 Nov;32(33):8548-54. [Content Brief]
[3]. Patlolla RR, et al. Folate-targeted etoposide-encapsulated lipid nanospheres. J Drug Target. 2008 May;16(4):269-75. [Content Brief]
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