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MedChemExpressModel Aripiprazole -129722-12-9

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Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19[1][2][3][4].
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Aripiprazole

MCE China:Aripiprazole

Brand:MedChemExpress (MCE)

Cat. No.HY-14546

CAS:129722-12-9

Synonyms:OPC-14597

Purity:99.95%

Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19.

In Vitro:Aripiprazole potently activates D2 receptor-mediated inhibition of cAMP accumulation[1]. Aripiprazole shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine[3].

In Vivo:Aripiprazole (0-3 mg/kg, IP, daily) shows some anxiolytic properties[4].

IC50 & Target:5-HT1A Receptor 4.2 nM (Ki) 5-HT2A Receptor 5-HT2B Receptor 5-HT2C Receptor D2 Receptor D3 Receptor D4 Receptor

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References:

[1]. Burris KD, et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):381-9.  [Content Brief]

[2]. Davies MA, et al. Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 2004 Winter;10(4):317-36.  [Content Brief]

[3]. Crespo-Facorro B, et al. Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis. Front Pharmacol. 2021 Mar 2;12:646701.  [Content Brief]

[4]. Russo E, et al. Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity. Neuropharmacology. 2013 Jan;64:371-9.  [Content Brief]

[5]. Stip E, et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.  [Content Brief]

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