MedChemExpress - Model PSMA-11 -1366302-52-4
PSMA-11 is a small molecule ligand that targets prostate-specific membrane antigen (PSMA) and has the ability to inhibit PSMA activity. PSMA-11 can be used to synthesize 68Ga-PSMA-11, a positron emission tomography (PET) tracer that can be used to image advanced prostate cancer[1][2][3].MCE products for research use only. We do not sell to patients.
PSMA-11
MCE China：PSMA-11
Brand：MedChemExpress (MCE)
Cat. No.HY-125399
CAS：1366302-52-4
Synonyms：HBED-CC-PSMA
Purity：99.74%
Storage：-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：PSMA-11 is a small molecule ligand that targets prostate-specific membrane antigen (PSMA) and has the ability to inhibit PSMA activity. PSMA-11 can be used to synthesize 68Ga-PSMA-11, a positron emission tomography (PET) tracer that can be used to image advanced prostate cancer.
In Vivo：PSMA-11 can be used to synthesize 68Ga-PSMA-11, which serves as a positron emission tomography (PET) tracer. [68Ga]Ga-PSMA-11 in vivo imaging[3]: 1. Inject 10-25 MBq of [68Ga]Ga-PSMA-11 into mice bearing LNCaP tumor xenografts via the caudal vein. 2. Anesthetized animals were placed in a small animal PET scanner and a 50-min dynamic microPET scan was recorded starting 1 min after injection, followed by a 20-min static scan. 3. Because [68Ga]Ga-PSMA-11 is rapidly cleared from blood and PSMA-negative tissues, organ and tumor uptake values for [68Ga]Ga-PSMA-11 reflect in vitro data.
IC50 & Target：Other
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References：
[1]. Demirci E, et al. Normal distribution pattern and physiological variants of 68Ga-PSMA-11 PET/CT imaging. Nucl Med Commun. 2016 Nov;37(11):1169-79. [Content Brief]
[2]. Eder M, et al. 68Ga-complex lipophilicity and the targeting property of a urea-based PSMA inhibitor for PET imaging[J]. Bioconjugate chemistry, 2012, 23(4): 688-697. [Content Brief]
[3]. Bois F, et al. [68Ga] Ga-PSMA-11 in prostate cancer: a comprehensive review[J]. American Journal of Nuclear Medicine and Molecular Imaging, 2020, 10(6): 349. [Content Brief]
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