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4-tert-Octylphenol

MCE China：4-tert-Octylphenol

Brand：MedChemExpress (MCE)

Cat. No.HY-B1941

CAS：140-66-9

Purity：99.70%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology.

In Vitro：4-tert-Octylphenol (0.01 and 1 μM, 24 h) may inhibit proliferation and promote apoptosis of neuronal progenitor cells during the early stage of brain development[1]. 4-tert-Octylphenol (10 μM, 6 h) down-regulates the expression of IL-12p35, IFN-γ2 and CXCb2 in LPS-stimulated monocytes/macrophages and decreases the levels of nitric oxide (NO) released from LPS-stimulated cells[3].

In Vivo：4-tert-Octylphenol (10, 50 mg/kg, s.c., a single dose) promotes cell death in offspring mouse brain, induces cognitive dysfunction and impairs sociability and decreases social novelty preference in offspring mice[1]. 4-tert-Octylphenol (10, 50 mg/kg, s.c., a single dose for 24 h) promotes cell cycle exit and inhibits cell cycle reentry of dentate gyrus (DG) neural progenitors in embryonic and adult neurogenesis[1]. 4-tert-Octylphenol (2.5 μg/kg, feed, daily for 14 days) lowers numbers of peritoneal leukocytes/phagocytes compared to those in control infected animals in peritoneal and head kidney leukocytes of fish[3].

IC50 & Target：Human Endogenous Metabolite

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References：

[1]. Dinh Nam Tran, et al. 4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions. Oxidative Medicine and Cellular Longevity, 2020.

[2]. Olaniyan LWB, et al. Environmental Water Pollution, Endocrine Interference and Ecotoxicity of 4-tert-Octylphenol: A Review[J]. Rev Environ Contam Toxicol. 2020;248:81-109.  [Content Brief]

[3]. Maciuszek M, et al. 17α-ethinylestradiol and 4-tert-octylphenol concurrently disrupt the immune response of common carp[J]. Fish Shellfish Immunol. 2020 Dec;107(Pt A):238-250.  [Content Brief]

[4]. Lee J, Zee S, et al. Effects of crosstalk between steroid hormones mediated thyroid hormone in zebrafish exposed to 4-tert-octylphenol: Estrogenic and anti-androgenic effects[J]. Ecotoxicol Environ Saf. 2024 Jun 1;277:116348.  [Content Brief]