MCE products for research use only. We do not sell to patients.

3-Aminoisobutyric acid

MCE China：3-Aminoisobutyric acid

Brand：MedChemExpress (MCE)

Cat. No.HY-W012974

CAS：144-90-1

Synonyms：β-Aminoisobutyric acid; BAIBA

Purity：98.0%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：3-Aminoisobutyric acid (β-Aminoisobutyric acid) has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid is a catabolic metabolite of thymine and valine in skeletal muscle.

In Vivo：Weight is slightly decreased in the mice by the end of 3-Amino-2-methylpropanoic acid (BAIBA) treatment. Analysis of body composition using MRI demonstrates BAIBA treatment significantly decreases body fat in the mice. Consistent with the effects on thermogenic and β-oxidation gene expression and body weights, analysis with metabolic cages indicates that oxygen consumption (VO2) and whole body energy expenditure are increased in the BAIBA treated mice without any significant difference in activity or food intake. The mice are also challenged with an intraperitoneal glucose tolerance test (IPGTT). BAIBA is found to significantly improve the glucose tolerance in the mice as determined by the area under the curve of the IPGTT[1].

Animal Administration：Mice[1] Six week old mice are either treated with 3-Amino-2-methylpropanoic acid (BAIBA:100 mg/kg/day) or remains untreated (control mice). Their weights are monitored weekly[1].

IC50 & Target：Microbial Metabolite Human Endogenous Metabolite

Hot selling product：Rasagiline  | Afatinib (dimaleate)  | Nicotiflorin  | TAK-285  | Perindopril (erbumine)  | L-Lysine hydrochloride  | Baloxavir marboxil  | Sophocarpine  | KOdiA-PC  | (-)-p-Bromotetramisole (oxalate)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

References：

[1]. Roberts LD, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 7;19(1):96-108.  [Content Brief]

[2]. Jung TW, et al. BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. Diabetologia. 2015 Sep;58(9):2096-105.  [Content Brief]

[3]. Audzeyenka I, et al. β-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes. Sci Rep. 2023 Jan 14;13(1):766.  [Content Brief]

[4]. Yi X, et al. Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill. Front Endocrinol (Lausanne). 2023 May 29;14:1192458.  [Content Brief]