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MedChemExpress - Model Ferroheme -14875-96-8
Ferroheme is a complex of ferrous ions and porphyrins, which exists in tissues in free form and as a prosthetic group of many heme proteins. In addition, ferroheme is also an isosteric inhibitor of fatty acid binding to rat liver fatty acid binding protein. Feraheme can be used in cardiovascular and neurological disease research.[1][2][3][4].MCE products for research use only. We do not sell to patients.
Ferroheme
MCE China：Ferroheme
Brand：MedChemExpress (MCE)
Cat. No.HY-111914A
CAS：14875-96-8
Purity：99.70%
Storage：-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Ferroheme is a complex of ferrous ions and porphyrins, which exists in tissues in free form and as a prosthetic group of many heme proteins. In addition, ferroheme is also an isosteric inhibitor of fatty acid binding to rat liver fatty acid binding protein. Feraheme can be used in cardiovascular and neurological disease research..
In Vivo：Feraheme (18 mg/kg, i.v.) reduces the infarct volume and improve the neurological function score in mice with permanent middle cerebral artery occlusion[4].
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References：
[1]. J M Stewart, et al. Ferriheme and ferroheme are isosteric inhibitors of fatty acid binding to rat liver fatty acid binding protein. Biochem Cell Biol. 1996;74(2):249-55. [Content Brief]
[2]. L Pauling, et al. The Magnetic Properties and Structure of Hemoglobin, Oxyhemoglobin and Carbonmonoxyhemoglobin. Proc Natl Acad Sci U S A. 1936 Apr;22(4):210-6. [Content Brief]
[3]. Derry P J, et al. The chemical basis of intracerebral hemorrhage and cell toxicity with contributions from eryptosis and ferroptosis[J]. Frontiers in Cellular Neuroscience, 2020, 14: 603043. [Content Brief]
[4]. Zhang B, et al. Effect of Ultramicro Superparamagnetic Iron Oxide Nanoparticles on Cerebral Infarction in Mice. J Nanosci Nanotechnol. 2020 Dec 1;20(12):7305-7310. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。