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MedChemExpressModel Edrecolomab -156586-89-9

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Edrecolomab (Panorex) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, expressed on epithelial tissues and on various carcinomas. Edrecolomab shows anti-tumor activity and can be used in colorectal carcinoma research[1][2].
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Edrecolomab

MCE China:Edrecolomab

Brand:MedChemExpress (MCE)

Cat. No.HY-P99231

CAS:156586-89-9

Synonyms:Panorex; CO17-1A

Purity:98.63%

Storage:Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping:Shipping with dry ice.

Description:Edrecolomab (Panorex) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, expressed on epithelial tissues and on various carcinomas. Edrecolomab shows anti-tumor activity and can be used in colorectal carcinoma research.

In Vitro:Edrecolomab (0-100 μg/mL; 20 h) shows moderate antibody-dependent cellular cytotoxicity (ADCC)[1].

In Vivo:Edrecolomab (intravenous injection; 30 μg/dose; day 1, 4 and 7 after tumor-cell inoculation) treatment inhibits tumor growth in the HT-29 nude mouse model[1].

Species:Mouse

Isotype:Mouse IgG2a kappa

Recommend Isotype Controls:Mouse IgG2a kappa, Isotype Control

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References:

[1]. Naundorf S, et al. In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment. Int J Cancer. 2002 Jul 1;100(1):101-10.  [Content Brief]

[2]. Punt CJ, et al. Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study. Lancet. 2002 Aug 31;360(9334):671-7.  [Content Brief]

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