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MedChemExpressModel Dexketoprofen (trometamol) -156604-79-4

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Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective COX inhibitor. Dexketoprofen trometamol has a pain-relieving effect, anti-inflammatory effect and anti-cancer effect[1][2][3][4][5].
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Dexketoprofen (trometamol)

MCE China:Dexketoprofen (trometamol)

Brand:MedChemExpress (MCE)

Cat. No.HY-B0714

CAS:156604-79-4

Synonyms:Dexketoprofen tromethamine salt

Purity:99.73%

Storage:4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective COX inhibitor. Dexketoprofen trometamol has a pain-relieving effect, anti-inflammatory effect and anti-cancer effect.

In Vitro:Dexketoprofen (3.125-800 μg/mL, 24 or 48 hours) significantly inhibits the viability of HeLa, HT-29, and MCF-7 cells, demonstrating anticancer activity[4].

In Vivo:Dexketoprofen (50, 70, 100 mg/kg, s.c., single dose) effectively prevents hyperalgesia (refers to abnormally increased sensitivity to pain stimuli) in a postoperative pain mouse model and inhibits microglial activation[3]. Dexketoprofen trometamol (7 mg/kg, applied topically as a transdermal gel, single dose) significantly reduces inflammation and oxidative stress in a xylene-induced ear edema rat model[5].

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References:

[1]. Magdi Hanna, et al. A review of dexketoprofen trometamol in acute pain. Curr Med Res Opin. 2019 Feb;35(2):189-202.  [Content Brief]

[2]. Romero-Alejo E, et al. Antihyperalgesic effects of dexketoprofen and tramadol in a model of postoperative pain in mice - effects on glial cell activation. J Pharm Pharmacol. 2016 Aug;68(8):1041-50.  [Content Brief]

[3]. Büyükfidan D, et al. The effects of dexketoprofen trometamol on incisional wound healing in a rat model: 9AP7-7[J]. European Journal of Anaesthesiology| EJA, 2011, 28: 144-145.

[4]. Marinov L, et al. The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines[J]. Pharmacia, 2024, 71: 1-12.

[5]. Soliman S M, et al. The deleterious effect of xylene-induced ear edema in rats: protective role of dexketoprofen trometamol transdermal invasomes via inhibiting the oxidative stress/NF-κB/COX-2 pathway[J]. International Journal of Pharmaceutics, 2023, 631: 122525.  [Content Brief]

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