- Home
- Companies
- MedChemExpress LLC (MCE)
- Products
- MedChemExpress - Model Dexketoprofen ...
MedChemExpress - Model Dexketoprofen (trometamol) -156604-79-4
Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective COX inhibitor. Dexketoprofen trometamol has a pain-relieving effect, anti-inflammatory effect and anti-cancer effect[1][2][3][4][5].MCE products for research use only. We do not sell to patients.
Dexketoprofen (trometamol)
MCE China:Dexketoprofen (trometamol)
Brand:MedChemExpress (MCE)
Cat. No.HY-B0714
CAS:156604-79-4
Synonyms:Dexketoprofen tromethamine salt
Purity:99.73%
Storage:4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Shipping:Room temperature in continental US; may vary elsewhere.
Description:Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective COX inhibitor. Dexketoprofen trometamol has a pain-relieving effect, anti-inflammatory effect and anti-cancer effect.
In Vitro:Dexketoprofen (3.125-800 μg/mL, 24 or 48 hours) significantly inhibits the viability of HeLa, HT-29, and MCF-7 cells, demonstrating anticancer activity[4].
In Vivo:Dexketoprofen (50, 70, 100 mg/kg, s.c., single dose) effectively prevents hyperalgesia (refers to abnormally increased sensitivity to pain stimuli) in a postoperative pain mouse model and inhibits microglial activation[3]. Dexketoprofen trometamol (7 mg/kg, applied topically as a transdermal gel, single dose) significantly reduces inflammation and oxidative stress in a xylene-induced ear edema rat model[5].
Hot selling product:Parathyroid Hormone (1-34), bovine | GW 590735 | G36 | Etravirine | Ofloxacin | Rhamnocitrin | Netilmicin (sulfate) | Cariprazine | Gamma-glutamylcysteine | Isosakuranetin
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References:
[1]. Magdi Hanna, et al. A review of dexketoprofen trometamol in acute pain. Curr Med Res Opin. 2019 Feb;35(2):189-202. [Content Brief]
[2]. Romero-Alejo E, et al. Antihyperalgesic effects of dexketoprofen and tramadol in a model of postoperative pain in mice - effects on glial cell activation. J Pharm Pharmacol. 2016 Aug;68(8):1041-50. [Content Brief]
[5]. Soliman S M, et al. The deleterious effect of xylene-induced ear edema in rats: protective role of dexketoprofen trometamol transdermal invasomes via inhibiting the oxidative stress/NF-κB/COX-2 pathway[J]. International Journal of Pharmaceutics, 2023, 631: 122525. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
