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MedChemExpressModel CG347B -1598426-03-9

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CG347B is a selective HDAC6 inhibitor, also involves in synthesis of other metalloenzyme inhibitors. HDAC6 inhibitors can be used for oncology, immunology, and neurology research[1][2].
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CG347B

MCE China:CG347B

Brand:MedChemExpress (MCE)

Cat. No.HY-135890

CAS:1598426-03-9

Purity:98.93%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping:Room temperature in continental US; may vary elsewhere.

Description:CG347B is a selective HDAC6 inhibitor, also involves in synthesis of other metalloenzyme inhibitors. HDAC6 inhibitors can be used for oncology, immunology, and neurology research.

In Vitro:HtrA1 is identified as a Cisplatin (HY-17394, CDDP) resistance-related gene in NSCLC cells, while CG347B shows no effect on normalized mRNA expression or protein level of HtrA1 in NCI-H460 (CDDP-resistant) cells[1]. CG347B (200 nM; 48 h) slightly rescues the Foxp3 expression inhibition induced by IL-4 (15 ng/mL), indicating a potential inhibition happens on histone deacetylation in naive CD4+ T cells from WT B6 mice cultured under Treg-polarizing conditions (for 1-3 d)[3].

IC50 & Target:HDAC6

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References:

[1]. Wang W, et al. Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer. Mol Cancer. 2020 Sep 2;19(1):134.  [Content Brief]

[2]. Christopher M. YATES. Metalloenzyme inhibitor compounds. WO2018165520A1.

[3]. Cui J, et al. IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation. Cell Death Dis. 2021 May 18;12(6):501.  [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
•   It has a professional experimental center and strict quality control and verification system;
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
•   The biological activity of the products has been verified by the experiments of customers in various countries;
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。