MCE products for research use only. We do not sell to patients.

Pantethine

MCE China：Pantethine

Brand：MedChemExpress (MCE)

Cat. No.HY-B1028

CAS：16816-67-4

Synonyms：D-Pantethine; LBF disulfide

Purity：99.91%

Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration.

In Vitro：Pantethine (10-1000 μM) inhibits cholesterol production in mouse liver slices[1]. Pantethine (250-1000 μM; 24 h and 72 h) reduces cholesterol levels in Vero E6 cells (35% at 24 h and 80% at 72 h)[2]. Pantethine(100-1000 μM; After pretreatment for 1 h, the virus is added and incubated together for 2 h until the end of the experiment) reduces the infection of SARS-CoV-2 to Vero E6 and Calu-3a cells in a dose-dependent manner, which has antiviral effect[2]. Pantethine (50-100 μM; 18 h) inhibits the release of microparticles (MPs) in a dose-dependent manner in endothelial HPMECs and HUVECs. (50-100 μM; 24 h) eliminates MP-induced oxidative and nitrosation stress in endothelial cells (HPMECs and HUVECs) and fibroblasts (NIH3T3)[5].

In Vivo：Pantethine (1.2 mmol/kg; Intragastrical administration (i.g.); Single dose) can reduce blood lipid in rats[1]. Pantethine (750 mg/kg; Intraperitoneal injection (i.p.); Once daily for 4 weeks) shows antitumor activity in mice with in-situ ovarian cancer [3]. Pantethine (150 mg/kg; p.o.; Once daily for 6 weeks) reduces skin and lung fibrosis associated with markers of oxidative and endothelial stress in mice with systemic sclerosis (SSc)[5]. Pantethine (15 mg/kg; Supplemented in daily drinking water, for 2 months) is able to effectively restore the disease status induced by the ketogenic diet in mice[6].

Hot selling product：VU 0364439  | NPS-2143 (hydrochloride)  | Tafamidis  | Naproxen  | Falcarindiol  | Prolactin Releasing Peptide (1-31), human (acetate)  | Demethoxycurcumin  | Orcinol glucoside  | Ximelagatran  | D-Xylulose

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

References：

[1]. Bocos C, et al. Pantethine stimulates lipolysis in adipose tissue and inhibits cholesterol and fatty acid synthesis in liver and intestinal mucosa in the normolipidemic rat. Environ Toxicol Pharmacol. 1998 Aug 4;6(1):59-66.  [Content Brief]

[2]. Abou-Hamdan M, et al. Potential antiviral effects of pantethine against SARS-CoV-2. Sci Rep. 2023 Feb 8;13(1):2237.  [Content Brief]

[3]. Penet MF, et al. Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism. Front Oncol. 2016 Nov 16;6:244.  [Content Brief]

[4]. Tóth F, et al. Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid. Int J Mol Sci. 2021 Jan 2;22(1):403.  [Content Brief]

[5]. Kavian N, et al. Pantethine Prevents Murine Systemic Sclerosis Through the Inhibition of Microparticle Shedding. Arthritis Rheumatol. 2015 Jul;67(7):1881-90.  [Content Brief]

[6]. Brunetti D, et al. Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model. Brain. 2014 Jan;137(Pt 1):57-68.  [Content Brief]