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MedChemExpress - Model Dehydroabietic acid -1740-19-8
Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice[1][2].MCE products for research use only. We do not sell to patients.
Dehydroabietic acid
MCE China：Dehydroabietic acid
Brand：MedChemExpress (MCE)
Cat. No.HY-N6869
CAS：1740-19-8
Purity：99.75%
Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice.
In Vitro：Dehydroabietic acid (0-100 μM, 30 min) decreases NO production in RAW264.7 cells[1]. Dehydroabietic acid (0-100 μM, 6 h) reduces the mRNA expression levels of inflammatory mediators including inducible nitric oxide (iNOS) and TNF-α in RAW264.7 cells[1]. Dehydroabietic acid (0-100 μM, 24 h) reduces the MyD88-induced NF-κB and AP-1 transcriptional activities in HEK293T cells[1]. Dehydroabietic acid (100 μM, 24 h) inactivates both Src and Syk kinases in Src- or Syk-overexpressing HEK293T cells[1]. Dehydroabietic acid (2.5-15 μM, 4 days) promotes 3T3-L1 adipocyte differentiation in a dose-dependent manner[2]. Dehydroabietic acid (10 μM, 0-6 days) increases mRNA expression of PPAR-γ target genes (Glut-4 and Cyp4a10) in 3T3-L1 cells[2].
In Vivo：Dehydroabietic acid (10-20 mg/kg, i.g., daily, 9 weeks) alleviates HFD-induced hepatic steatosis and inflammation in HFD mice[2].
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References：
[1]. Kim E, et al. Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways. Int J Mol Sci. 2019 Mar 29;20(7):1593. [Content Brief]
[2]. Xie Z, et al. Dehydroabietic acid alleviates high fat diet-induced insulin resistance and hepatic steatosis through dual activation of PPAR-γ and PPAR-α. Biomed Pharmacother. 2020 Jul;127:110155. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。