MedChemExpress - Model AR-C102222 hydrochloride -1781934-50-6
AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM[1]. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities[2].MCE products for research use only. We do not sell to patients.
AR-C102222 hydrochloride
MCE China：AR-C102222 hydrochloride
Brand：MedChemExpress (MCE)
Cat. No.HY-12122A
CAS：1781934-50-6
Purity：99.83%
Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities.
In Vivo：AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity[2]. AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model[3].
IC50 & Target：iNOS
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References：
[1]. Tinker AC, et al. 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J Med Chem. 2003 Mar 13;46(6):913-6. [Content Brief]
[2]. LaBuda CJ, et al. Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain. Eur J Pain. 2006 Aug;10(6):505-12. Epub 2005 Aug 24. [Content Brief]
[3]. Yoon J, et al. Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1953-7. [Content Brief]
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