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MedChemExpressModel Palivizumab -188039-54-5

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Palivizumab (MEDI 493) is a humanized monoclonal antibody against respiratory syncytial virus (RSV). Palivizumab can bind to RSV F protein with a Kd value of 1.4 nM. Palivizumab can prevent respiratory syncytial virus infection in cotton mice[1].
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Palivizumab

MCE China:Palivizumab

Brand:MedChemExpress (MCE)

Cat. No.HY-P9944

CAS:188039-54-5

Synonyms:MEDI 493

Purity:99.43%

Storage:Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping:Shipping with dry ice.

Description:Palivizumab (MEDI 493) is a humanized monoclonal antibody against respiratory syncytial virus (RSV). Palivizumab can bind to RSV F protein with a Kd value of 1.4 nM. Palivizumab can prevent respiratory syncytial virus infection in cotton mice.

In Vitro:Palivizumab has RSV neutralizing activity and an EC50 value of 0.95850 nM with IgG1 protein[2].

In Vivo:Palivizumab (0.625-5 mg/kg (i.m.) or 0.312-10 mg/kg (i.v.); single dose) can prevent respiratory syncytial virus infection in cotton mice[1]. Palivizumab (0.05 mg/kg; single dose; intranasally administered)can prevent RSV infection in mice[2]. Palivizumab (15 mg/kg; single dose; s.c.) can inhibit RSV induced airway neurogenic inflammation in rats[3].

Species:Humanized

Isotype:Human IgG1 kappa

Recommend Isotype Controls:Human IgG1 kappa, Isotype Control

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References:

[1]. Johnson S, et al. Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus. J Infect Dis. 1997 Nov;176(5):1215-24.  [Content Brief]

[2]. Jacobino SR, et al. Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo. MAbs. 2018 Apr;10(3):453-462.  [Content Brief]

[3]. Piedimonte G, et al. A humanized monoclonal antibody against respiratory syncytial virus (palivizumab) inhibits RSV-induced neurogenic-mediated inflammation in rat airways. Pediatr Res. 2000 Mar;47(3):351-6.  [Content Brief]

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