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MedChemExpressModel 3-Hydroxydodecanoic acid -1883-13-2

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3-Hydroxydodecanoic acid is a medium-chain fatty acid associated with fatty acid metabolic disorders.
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3-Hydroxydodecanoic acid

MCE China:3-Hydroxydodecanoic acid

Brand:MedChemExpress (MCE)

Cat. No.HY-113107

CAS:1883-13-2

Purity:98.0%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping:Room temperature in continental US; may vary elsewhere.

Description:3-Hydroxydodecanoic acid is a medium-chain fatty acid. 3-Hydroxydodecanoic acid activates GPR84 and promotes IL-12 production. 3-Hydroxydodecanoic acid has anticancer activity against colon cancer, lung cancer, and melanoma.

In Vitro:3-Hydroxydodecanoic acid (1-100 μM, 1 h) induces lipid peroxidation in rat cerebral cortex, with increasing TBA-RS levels[1].

In Vivo:3-Hydroxydodecanoic acid (i.p., days 6, 9, and 12) shows anti-tumor effect via GPR84 activation and IL-12 production in mice carrying MC38 tumors[2]..

IC50 & Target:Human Endogenous Metabolite

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References:

[1]. Tonin AM, et al. Long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies induce oxidative stress in rat brain. Neurochem Int. 2010 Jul;56(8):930-6.  [Content Brief]

[2]. Katkeviciute E, et al. Bacteria-derived 3-hydroxydodecanoic acid induces a potent anti-tumor immune response via the GPR84 receptor. Cell Rep. 2025 Feb 26;44(3):115357.  [Content Brief]

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