MedChemExpress - Model 3-Hydroxydodecanoic acid -1883-13-2
3-Hydroxydodecanoic acid is a medium-chain fatty acid associated with fatty acid metabolic disorders.MCE products for research use only. We do not sell to patients.
3-Hydroxydodecanoic acid
MCE China:3-Hydroxydodecanoic acid
Brand:MedChemExpress (MCE)
Cat. No.HY-113107
CAS:1883-13-2
Purity:98.0%
Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping:Room temperature in continental US; may vary elsewhere.
Description:3-Hydroxydodecanoic acid is a medium-chain fatty acid. 3-Hydroxydodecanoic acid activates GPR84 and promotes IL-12 production. 3-Hydroxydodecanoic acid has anticancer activity against colon cancer, lung cancer, and melanoma.
In Vitro:3-Hydroxydodecanoic acid (1-100 μM, 1 h) induces lipid peroxidation in rat cerebral cortex, with increasing TBA-RS levels[1].
In Vivo:3-Hydroxydodecanoic acid (i.p., days 6, 9, and 12) shows anti-tumor effect via GPR84 activation and IL-12 production in mice carrying MC38 tumors[2]..
IC50 & Target:Human Endogenous Metabolite
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References:
[1]. Tonin AM, et al. Long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies induce oxidative stress in rat brain. Neurochem Int. 2010 Jul;56(8):930-6. [Content Brief]
[2]. Katkeviciute E, et al. Bacteria-derived 3-hydroxydodecanoic acid induces a potent anti-tumor immune response via the GPR84 receptor. Cell Rep. 2025 Feb 26;44(3):115357. [Content Brief]
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