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MedChemExpress - Model Cobolimab -2022215-65-0
Cobolimab (TSR-022) is an anti-TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC50 value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC)[1][2][3].MCE products for research use only. We do not sell to patients.
Cobolimab
MCE China:Cobolimab
Brand:MedChemExpress (MCE)
Cat. No.HY-P99827
CAS:2022215-65-0
Synonyms:TSR-022; GSK4069889
Purity:98.00%
Storage:Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping:Shipping with dry ice.
Description:Cobolimab (TSR-022) is an anti-TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC50 value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC).
In Vitro:Cobolimab (0.0001-10 nM; 3 d) promotes TIM-3 internalization in a dose dependent manner in pre-activated T cells with an IC50 value of 0.4464 nM[3]. Cobolimab (20 µg/mL; 24 h) significantly increases CD8+ T cell content by inhibiting TIM-3[4].
Species:Humanized
Isotype:Human IgG4 kappa
Recommend Isotype Controls:Human IgG4 (S228P) kappa, Isotype Control
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References:
[2]. Markham A. Dostarlimab: First Approval. Drugs. 2021 Jul;81(10):1213-1219. [Content Brief]
[3]. Kuang Z, et al. A novel antibody targeting TIM-3 resulting in receptor internalization for cancer immunotherapy. Antib Ther. 2020 Nov 9;3(4):227-236. [Content Brief]
[4]. Sun CY, et al. T cell exhaustion drives osteosarcoma pathogenesis. Ann Transl Med. 2021 Sep;9(18):1447. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
