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MedChemExpress - Model ODN 1826 - ...

MedChemExpress - Model ODN 1826 -202668-42-6

ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’[1][2][3][4].

ODN 1826

MCE China：ODN 1826

Brand：MedChemExpress (MCE)

Cat. No.HY-146245

CAS：202668-42-6

Synonyms：CpG 1826

Storage：-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’.

In Vitro：ODN 1826 (1 μg/mL, 24 h) can stimulate the production of NO and iNOS in RAW 264.7 cells [2].

In Vivo：ODN 1826 (18 nM, subcutaneous injection, 3 times a week for 7 weeks) increases aortic atherosclerotic plaque size in a mouse model of chronic vascular injury [1]. ODN 1826 (0.05 mg, intraperitoneally injected , 1, 3, 5, 8, 11, 13 days) has a strong anti-tumor growth effect[3].

IC50 & Target：TLR9

Sequence：DNA, d(P-thio)(T-C-C-A-T-G-A-C-G-T-T-C-C-T-G-A-C-G-T-T)

References：

[1]. Krogmann AO, et al. Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice. PLoS One. 2016 Jan 11;11(1):e0146326. [Content Brief]

[2]. Utaisincharoen P, et al. CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7). Clin Exp Immunol. 2002 Jun;128(3):467-73. [Content Brief]

[3]. Yuan S, et al. CpG oligodeoxynucleotide 1826 enhances the Lewis lung cancer response to radiotherapy in murine tumor. Cancer Biother Radiopharm. 2011 Apr;26(2):203-8. [Content Brief]

[4]. Zhang X, et al. The toll-like receptor 9 agonist, CpG-oligodeoxynucleotide 1826, ameliorates cardiac dysfunction after trauma-hemorrhage. Shock. 2012 Aug;38(2):146-52. [Content Brief]

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MedChemExpress - Model ODN 1826 -202668-42-6

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ODN 1826