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Diallyl Trisulfide

MCE China：Diallyl Trisulfide

Brand：MedChemExpress (MCE)

Cat. No.HY-117235

CAS：2050-87-5

Purity：95.0%

Storage：-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Diallyl Trisulfide is an orally active anticancer agent that can be isolated from garlic. Diallyl Trisulfide has the ability to induce apoptosis and exhibits anticancer, anti-inflammatory, antioxidant, and antibacterial activities. Diallyl Trisulfide can be used to study a variety of cancers, including liver, colon and prostate cancer.

In Vitro：Diallyl Trisulfide (25-100 μM; 24-72 h) induces apoptosis and inhibits cell proliferation in A549 cells, exhibiting anticancer activity[1]. Diallyl Trisulfide (5-10 μM; 1 h) significantly inhibits naphthalene (20 μM)-stimulated ROS generation and reduces the levels of inflammatory factors IL-6, TNF-α, and IL-8 by increasing superoxide dismutase (SOD) activity, thereby possessing antioxidant and anti-inflammatory activities[2]. Diallyl Trisulfide (93.75-375 µM; 24 h) attenuates H9N2 avian influenza virus (AIV) infection in human lung A549 epithelial cells, demonstrating antiviral activity[3]. Diallyl Trisulfide inhibits the growth of Penicillium expansum with antifungal activity (minimum fungicidal concentration (MFC)99 value: ≤ 90 μg/mL)[4].

In Vivo：Diallyl Trisulfide (6 μM/animal; Oral gavage, every other day for 30 days) inhibits tumor growth and exhibits anticancer activity in BALB/c nude mice[1]. Diallyl Trisulfide (20-80 mg/kg; Oral gavage, single dose) demonstrates antioxidant and anti-inflammatory activities in Kunming mice induced by naphthalene (100 mg/kg; orally, single dose)[2]. Diallyl Trisulfide (30 mg/kg; intraperitoneal injection; once daily for 2 weeks) reduces lung edema and inflammation caused by H9N2 AIV infection in BABL/c mice, exhibiting antiviral activity[3].

IC50 & Target：IL-6 IL-8

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References：

[1]. Li W, et al. Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2012 Jul;44(7):577-83.  [Content Brief]

[2]. Zhang F, et al. Diallyl trisulfide inhibits naphthalene-induced oxidative injury and the production of inflammatory responses in A549 cells and mice. Int Immunopharmacol. 2015 Dec;29(2):326-333.  [Content Brief]

[3]. Ming L, et al. Antiviral activity of diallyl trisulfide against H9N2 avian influenza virus infection in vitro and in vivo. Virol J. 2021 Aug 19;18(1):171.  [Content Brief]

[4]. Pu Liu, et al. Diallyl trisulfide (DATS) effectively induced apoptosis of postharvest diseasePenicillium expansum of citrus. Annals of Microbiology. December 2009, Volume 59, Issue 4, pp 675-679.