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MedChemExpressModel Narsoplimab -2108782-45-0

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Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2[1].
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Narsoplimab

MCE China:Narsoplimab

Brand:MedChemExpress (MCE)

Cat. No.HY-P99376

CAS:2108782-45-0

Synonyms:OMS 721; Anti-MASP2 Reference Antibody (narsoplimab)

Purity:95.0%

Storage:Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping:Shipping with dry ice.

Description:Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.

In Vitro:Narsoplimab (100 nM; 3 h; Vero E6 cells and Vero E6 cells with SARS-CoV-2) inhibits the N protein potentiated MASP-2 deposition[1].

In Vivo:Narsoplimab (10 mg/kg; i.v.; WT and Masp2-/- (KO) mice) decreases percentage of lymphocytes (Lym%) and increases percentage of neutrophils (Neu%)[1].

Species:Human

Isotype:Human IgG4 lambda

Recommend Isotype Controls:Human IgG4 (S228P) lambda1, Isotype Control

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References:

[1]. Gao T, et, al. Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation. Signal Transduct Target Ther. 2022 Sep 14;7(1):318.  [Content Brief]

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