MedChemExpress - Model Narsoplimab -2108782-45-0
Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2[1].MCE products for research use only. We do not sell to patients.
Narsoplimab
MCE China:Narsoplimab
Brand:MedChemExpress (MCE)
Cat. No.HY-P99376
CAS:2108782-45-0
Synonyms:OMS 721; Anti-MASP2 Reference Antibody (narsoplimab)
Purity:95.0%
Storage:Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping:Shipping with dry ice.
Description:Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.
In Vitro:Narsoplimab (100 nM; 3 h; Vero E6 cells and Vero E6 cells with SARS-CoV-2) inhibits the N protein potentiated MASP-2 deposition[1].
In Vivo:Narsoplimab (10 mg/kg; i.v.; WT and Masp2-/- (KO) mice) decreases percentage of lymphocytes (Lym%) and increases percentage of neutrophils (Neu%)[1].
Species:Human
Isotype:Human IgG4 lambda
Recommend Isotype Controls:Human IgG4 (S228P) lambda1, Isotype Control
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References:
[1]. Gao T, et, al. Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation. Signal Transduct Target Ther. 2022 Sep 14;7(1):318. [Content Brief]
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