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MedChemExpressModel PSMA I&T -2192281-54-0

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PSMA I&T is an effective inhibitor of prostate-specific membrane antigen (PSMA). PSMA I&T can be used for SPECT/CT imaging and radionuclide studies in triple-negative breast cancer and prostate cancer (PCa)[1][2].
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PSMA I&T

MCE China:PSMA I&T

Brand:MedChemExpress (MCE)

Cat. No.HY-148761

CAS:2192281-54-0

Purity:99.67%

Storage:-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:PSMA I&T is an effective inhibitor of prostate-specific membrane antigen (PSMA). PSMA I&T can be used for SPECT/CT imaging and radionuclide studies in triple-negative breast cancer and prostate cancer (PCa).

In Vitro:PSMA I&T has high specificity for PSMA-expressing PCa cells, xenografted PCa, and in vitro kidneys, with equilibrium binding constants Kd of 3.9 nM and 5.6 nM for LNCaP and LS174T-PSMA, respectively[1].

In Vivo:PSMA I&T (0.1-1 nM, intravenous injection, single dose) shows specific accumulation in mouse xenografts, kidneys, spleens, lungs, salivary glands, and adrenal glands[1].

IC50 & Target:PSMA[1] In Vitro PSMA I&T has high specificity for PSMA-expressing PCa cells, xenografted PCa, and in vitro kidneys, with equilibrium binding constants Kd of 3.9 nM and 5.6 nM for LNCaP and LS174T-PSMA, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PSMA I&T Related Antibodies

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References:

[1]. Chatalic KL, et al. Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent. Theranostics. 2016 Apr 12;6(6):849-61.  [Content Brief]

[2]. Amelie Heesch, et al. The prostate-specific membrane antigen holds potential as a vascular target for endogenous radiotherapy with [177Lu]Lu-PSMA-I&T for triple-negative breast cancer. Breast Cancer Res. 2024 Feb 20;26(1):30.  [Content Brief]

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