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MedChemExpressModel Levomenol -23089-26-1

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Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active[1][2].
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Levomenol

MCE China:Levomenol

Brand:MedChemExpress (MCE)

Cat. No.HY-N6967

CAS:23089-26-1

Synonyms:(-)-α-Bisabolol

Purity:99.22%

Storage:Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active.

In Vivo:Levomenol ((-)-α-Bisabolol) (100-200 mg/kg; p.o.; one day before and 1 h after pMCAO; once daily for the following five day; Male Swiss mice) significantly reduces the infarcted area and neurological deficits caused by pMCAO[1]. pMCAO: permanent media cerebral artery occlusion. (?)-α-bisabolol exerts anti-inflammatory effects by reducing astrogliosis, MPO activity, and TNF-α and iNOS production[1].

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References:

[1]. Fernandes MYD, et al. (-)-α-bisabolol prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Eur J Pharmacol. 2019 Jan 5;842:270-280.  [Content Brief]

[2]. Melo LT, et al. (-)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury. Life Sci. 2019 Jun 15;227:122-128.  [Content Brief]

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