MedChemExpress - Model Methylprednisolone succinate sodium -2375-03-3
Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium, a glucocorticoid, is a immunosuppressive agent with anti-inflammatory effects[1].MCE products for research use only. We do not sell to patients.
Methylprednisolone succinate sodium
MCE China：Methylprednisolone succinate sodium
Brand：MedChemExpress (MCE)
Cat. No.HY-B1060
CAS：2375-03-3
Synonyms：Methylprednisolone hydrogen succinate sodium
Purity：99.04%
Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium, a glucocorticoid, is a immunosuppressive agent with anti-inflammatory effects.
In Vitro：Methylprednisolone succinate sodium (1-400 μg; 2 days) inhibits cell growth of human glioblastomas in a dose-dependent manner[2].
In Vivo：Administration of Methylprednisolone succinate sodium post- intracranial haemorrhage (ICH) significantly reduces permeability of the blood-brain barrier (BBB) and brain oedema and upregulated expression of ZO-1 and Occludin. Methylprednisolone succinate sodium inhibits inflammatory responses, including reducing proinflammatory cytokines (IL-1β, TNF-α), suppressing infiltration of neutrophils and activation of microglia. In addition, Methylprednisolone succinate sodium reduces neuronal apoptosis through increasing Bcl-2 expression and reducing Bax expression[1].
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References：
[1]. Cheng S, Gao W, Xu X, et al. Methylprednisolone sodium succinate reduces BBB disruption and inflammation in a model mouse of intracranial haemorrhage. Brain Res Bull. 2016;127:226-233. [Content Brief]
[2]. J Mealey Jr, et al. Effects of dexamethasone and methylprednisolone on cell cultures of human glioblastomas. J Neurosurg. 1971 Mar;34(3):324-34. [Content Brief]
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