MedChemExpress - Model Sotrovimab -2423014-07-5
Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease[1][2].MCE products for research use only. We do not sell to patients.
Sotrovimab
MCE China：Sotrovimab
Brand：MedChemExpress (MCE)
Cat. No.HY-P99340
CAS：2423014-07-5
Synonyms：VIR 7831
Purity：98.00%
Storage：Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping：Shipping with dry ice.
Description：Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease.
In Vitro：Sotrovimab neutralizes both SARS-CoV-2 and SARS-CoV, but does not directly block virus receptor binding[2]. Sotrovimab (100 μg/mL, injected for 200 s, v=30 μL/min) binds efficiently to surface-expressed SARS-CoV-2 S[3]. Sotrovimab (0.3 ng/mL-20 mg/mL; 30 min) neutralizes SARS-CoV-2 pseudo-typed virus in vitro, and also against the Alpha, Beta, Gamma, Delta and Kappa variant viruses with IC50s of 187.2 ng/mL, 71.9 ng/mL, 73.11 ng/mL, 51.3 ng/mL, and 118.64 ng/mL, respectively[3].
In Vivo：Sotrovimab (5 mg/kg, 10 mL; via intravenous catheter; single dose) provides protective exposures against susceptible variants in the lung of female cynomolgus monkey for up to 28 days[3].
Species：Human
Isotype：Human IgG1 kappa
Recommend Isotype Controls：Human IgG1 kappa, Isotype Control
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References：
[1]. Gupta A, et al; COMET-ICE Investigators. Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab. N Engl J Med. 2021 Nov 18;385(21):1941-1950. [Content Brief]
[2]. Case JB, et al. Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains. Nat Commun. 2022 Jul 2;13(1):3824. [Content Brief]
[4]. Aweda TA, et al. In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys. Eur J Nucl Med Mol Imaging. 2022 Oct 28:1–12. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
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