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MedChemExpress - Model (-)-Fucose -2438-80-4
(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth[2].MCE products for research use only. We do not sell to patients.
(-)-Fucose
MCE China：(-)-Fucose
Brand：MedChemExpress (MCE)
Cat. No.HY-N1480
CAS：2438-80-4
Synonyms：6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose
Purity：98.0%
Storage：-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth.
In Vitro：(-)-Fucose (8-80 mM) inhibits the CL-11 binding to immobilized ligand and eliminates the trigger for complement activation with IC50 of 12.2 mM[2].
In Vivo：(-)-Fucose (100mg, i.p., single or double dosage) blocks the CL-11 associated complement C3d deposition on hypoxic renal tubules cells, reveals a protective effect against I/R injury with CL11 dependence in C57BL/6 mice[2]. (-)-Fucose (1-5 g/kg/d, i.p. for 11 days) inhibits tumor growth and mitotic activity, promotes tumor metastasis in solid Ehrlich tumour (SET) bearing NMRI mice[3].
IC50 & Target：Human Endogenous Metabolite
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References：
[1]. Becker DJ, et al. Fucose: biosynthesis and biological function in mammals. Glycobiology. 2003 Jul;13(7):41R-53R. [Content Brief]
[2]. Howard MC, et al., l-Fucose prevention of renal ischaemia/reperfusion injury in Mice. FASEB J. 2020 Jan;34(1):822-834. [Content Brief]
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