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MedChemExpress - Model Allura Red AC - ...

MedChemExpress - Model Allura Red AC -25956-17-6

Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety[1][2][3].

Allura Red AC

MCE China：Allura Red AC

Brand：MedChemExpress (MCE)

Cat. No.HY-123630

CAS：25956-17-6

Synonyms：FD&C RED NO. 40; CI 16035

Purity：98.01%

Storage：-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety.

In Vitro：Allura Red AC (1 pmol/L, 24 h) promotes 5-HT secretion, upregulates TPH1, and enhances ROS generation in BON cells (EC cell (Enterochromaffin cells) model)[3].

In Vivo：Allura Red AC (100 ppm, Ad libitum intake for 12 weeks) exacerbates colitis in the DSS-induced colitis C57BL/6 mouse model and enhances inflammation through 5-HT-mediated mechanisms[3]. Allura Red AC (100 ppm (100 mg of Allura Red AC per 1 kg of diet), Ad libitum intake for 5 weeks) exacerbates colitis in the CD4+CD45RBhi T cell-induced colitis Rag1-/- mouse model and promotes T cell-mediated inflammation[3]. Allura Red AC (500-2000 mg/kg, p.o., single dose) shows no in vivo genotoxic potential in mice[2].

References：

[1]. Di Wu, et al. Characterisation of Interaction Between Food Colourant Allura Red AC and Human Serum Albumin: Multispectroscopic Analyses and Docking Simulations. Food Chem. 2015 Mar 1;170:423-9. [Content Brief]

[2]. Honma M. Evaluation of the in vivo genotoxicity of Allura Red AC (Food Red No. 40). Food Chem Toxicol. 2015 Oct;84:270-5. [Content Brief]

[3]. Kwon YH, et al. Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nat Commun. 2022 Dec 20;13(1):7617. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
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•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。

MedChemExpress - Model Allura Red AC -25956-17-6

MCE products for research use only. We do not sell...

Allura Red AC