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MedChemExpress - Model Ursocholic acid -2955-27-3
Ursocholic acid, a bile acid present in mammalian bile, is converted to deoxycholic acid (UDC) by the mouse intestinal flora. Ursocholic acid acts as a gallstone dissolving agent in the liver through anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling, Ursocholic acid also has favorable effects on bones in patients with chronic cholestasis[1][2][3][4][5].MCE products for research use only. We do not sell to patients.
Ursocholic acid
MCE China：Ursocholic acid
Brand：MedChemExpress (MCE)
Cat. No.HY-113212
CAS：2955-27-3
Purity：99.91%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Ursocholic acid, a bile acid present in mammalian bile, is converted to deoxycholic acid (UDC) by the mouse intestinal flora. Ursocholic acid acts as a gallstone dissolving agent in the liver through anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling, Ursocholic acid also has favorable effects on bones in patients with chronic cholestasis.
In Vitro：Ursocholic acid (1 μM, 10 μM, 100 μM and 1 mM, 24-72 h) has no deleterious effect on osteoblast survival at a lower concentration (100 μM), increases osteoblast differentiation treated with LCA (10 μM), and neutralizes the deleterious effects of bilirubin (50 μM)[5]. Ursocholic acid (1 μM, 10 μM and 100 μM, 7-28 days) increases osteoblast mineralization by 35% and 9% at days 21 and 28 at a dose of 100 μM[5].
In Vivo：Ursocholic acid (10, 100 and 500 mg/kg, i.g.; once daily for 6 days) reduces significantly inflammatory cytokine levels and intestinal villus damage in Sprague-Dawley rats[4].
IC50 & Target：Human Endogenous Metabolite
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References：
[1]. MacDonald IA, et al. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms. Appl Environ Microbiol. 1982 Nov;44(5):1187-95. [Content Brief]
[2]. Lee HI, et al. Ursodeoxycholic acid, an inhibitor of hepatocyte nuclear factor 1α, did not increase the systemic exposure of pitavastatin. Int J Clin Pharmacol Ther. 2014 Nov;52(11):981-5. [Content Brief]
[3]. Ikegami, et al. Ursodeoxycholic acid: mechanism of action and novel clinical applications. Hepatology Research 38.2 (2008): 123-131. [Content Brief]
[4]. Kim, et al. Ursodeoxycholic acid attenuates 5‑fluorouracil‑induced mucositis in a rat model. Oncology letters 16.2 (2018): 2585-2590. [Content Brief]
[5]. Dubreuil, et al. Ursodeoxycholic acid increases differentiation and mineralization and neutralizes the damaging effects of bilirubin on osteoblastic cells. Liver international 33.7 (2013): 1029-1038. [Content Brief]
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