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MedChemExpress - Model L-Ornithine L-aspartate -3230-94-2
L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions[1][2][3][4].MCE products for research use only. We do not sell to patients.
L-Ornithine L-aspartate
MCE China：L-Ornithine L-aspartate
Brand：MedChemExpress (MCE)
Cat. No.HY-A0282
CAS：3230-94-2
Purity：98.0%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions.
In Vitro：L-Ornithine L-aspartate (5 mM, 24 h) increases the redox activity of mitochondria in SH-SY5Y cells, and counteracts ROT- and 6-OHDA- induced mitochondrial depolarization[4].
In Vivo：L-Ornithine L-aspartate (300 mg/kg/h, i.v. infusions) prevents ammonia-precipitated coma in portal-systemic encephalopathy (PSE) rats[2]. L-Ornithine L-aspartate (2 g/kg, p.o. for 10 days) protects Thioacetamide (HY-Y0698)-induced hepatic damage in rats[3].
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References：
[1]. Sikorska H, et al. [Physiological functions of L-ornithine and L-aspartate in the body and the efficacy of administration of L-ornithine-L-aspartate in conditions of relative deficiency]. Pol Merkur Lekarski. 2010 Jun;28(168):490-5. [Content Brief]
[2]. Rose C, et al. L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metab Brain Dis. 1998 Jun;13(2):147-57. [Content Brief]
[3]. Najmi AK, et al. Effect of l-ornithine l-aspartate against thioacetamide-induced hepatic damage in rats. Indian J Pharmacol. 2010 Dec;42(6):384-7. [Content Brief]
[4]. Sisalli MJ, et al. L-Ornithine L-Aspartate Restores Mitochondrial Function and Modulates Intracellular Calcium Homeostasis in Parkinson's Disease Models. Cells. 2022 Sep 17;11(18):2909. [Content Brief]
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