MCE products for research use only. We do not sell to patients.

Oxfenicine

MCE China：Oxfenicine

Brand：MedChemExpress (MCE)

Cat. No.HY-W018026

CAS：32462-30-9

Synonyms：L-p-Hydroxyphenylglycine; 4-Hydroxy-L-phenylglycine; UK 25842

Purity：99.76%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Oxfenicine (L-p-Hydroxyphenylglycine) is an orally active carnitine palmitoyltransferase-1 inhibitor. Oxfenicine inhibits the oxidation of fatty acids in the heart, protecting cardiac tissue from necrotic damage during ischemia, and also has an inhibitory effect on cardiac tissue apoptosis. In addition, Oxfenicine promotes lipolysis in a high-fat diet rat model. Oxfenicine can be used in the study of cardiovascular and metabolic diseases.

In Vitro：Oxfenicine (1 mM, 2 hours) reduces fatty acid oxidation and glucose incorporation into lipids in subcutaneous and epididymal adipocytes[4]. Oxfenicine (10 mM, 24 hours) blunts carnitine plus palmitate-induced formation of apoptotic nuclei in chick embryonic ventricular cells[5].

In Vivo：Oxfenicine (150 mg/kg, i.p., once daily for 3 weeks) treatment significantly reduces adiposity in high-fat diet rats[4].

IC50 & Target：carnitine palmitoyltransferase-1[1] In Vitro Oxfenicine (1 mM, 2 hours) reduces fatty acid oxidation and glucose incorporation into lipids in subcutaneous and epididymal adipocytes[4]. Oxfenicine (10 mM, 24 hours) blunts carnitine plus palmitate-induced formation of apoptotic nuclei in chick embryonic ventricular cells[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Oxfenicine Related Antibodies Apoptosis Analysis[5] Cell Line: Carnitine and Palmitate-induced chick embryonic ventricular cells (7-day-old chick embryos from white Leghorn eggs)

Hot selling product：Efavirenz  | Pyrroloquinoline quinone (disodium salt)  | Daxdilimab  | GSK467  | 5-FAM  | Peimine  | KR-33493  | DCZ0415  | Caffeic acid  | Halicin

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

References：

[1]. Stephens TW, et, al. Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine. Biochem J. 1985 Apr 15;227(2):651-60.  [Content Brief]

[2]. Greaves P, et, al. Cardiac hypertrophy in the dog and rat induced by oxfenicine, an agent which modifies muscle metabolism. Arch Toxicol Suppl. 1984;7:488-93.  [Content Brief]

[3]. Kennedy JA, et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. J Cardiovasc Pharmacol. 2000 Dec;36(6):794-801.  [Content Brief]

[4]. Sepa-Kishi DM, et al. Antilipolytic and antilipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats. Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311(4):R779-R787.  [Content Brief]

[5]. Kong JY, et al. Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin. Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H717-25.  [Content Brief]