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Chlorogenic acid

MCE China：Chlorogenic acid

Brand：MedChemExpress (MCE)

Cat. No.HY-N0055

CAS：327-97-9

Synonyms：3-O-Caffeoylquinic acid; Heriguard; NSC-407296

Purity：99.53%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound.

In Vitro：Chlorogenic acid (10 μM, 16 h) decreases HIF-1α protein levels in CoCl2 induced hypoxic A549 cells, but does not affect HIF-1α mRNA level[1]. Chlorogenic acid (10 μM, 24 h) inhibits the hypoxia-induced HUVEC cell migration, invasion and tube formation of vascular endothelial cells[1]. Chlorogenic acid (25, 50 μM, 24 h) inhibits cell proliferation of Huh7 cells, and reduces the number of invading and migrating cells[4].

In Vivo：Chlorogenic acid (10 μM, s.c.) inhibits VEGF (200 ng/mL)-induced angiogenesis in C57BL/6J mice, by suppression of AKT activation (Matrigel plug assay)[1]. Chlorogenic acid (10-100 mg/kg, p.o.) shows protective effects against experimental reflux esophagitis in rats[3]. Chlorogenic acid (10 mg/kg, i.v.) prevents endotoxic mortality and induced TNF-α release of LPS-intoxicated C57BL/6 mice, and ameliorates acute liver injury of LPS/GalN-challenged mice[2]. Chlorogenic acid (ip, 25-200 mg/kg) inhibits tumor growth in NOD/SCID mice inoculated with Huh7 or H446 cells[4].

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References：

[1]. Park JJ, et al. Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway. Cell Oncol (Dordr). 2015 Jan 6.  [Content Brief]

[2]. Park SH, et al. IRAK4 as a Molecular Target in the Amelioration of Innate Immunity-Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid. J Immunol. 2015 Feb 1;194(3):1122-30.  [Content Brief]

[3]. Kang JW, et al. Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. Biomol Ther (Seoul). 2014 Sep;22(5):420-5.  [Content Brief]

[4]. Huang S, et al. Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation. Theranostics. 2019 Sep 19;9(23):6745-6763.  [Content Brief]