MedChemExpress LLC (MCE)

MedChemExpressModel Briakinumab -339308-60-0

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Briakinumab (ABT-874) is a fully human anti-IL-12/23p40 monoclonal antibody. Briakinumab targets and neutralizes IL-12 and IL-23. Briakinumab can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis[1].
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Briakinumab

MCE China:Briakinumab

Brand:MedChemExpress (MCE)

Cat. No.HY-P99486

CAS:339308-60-0

Synonyms:ABT-874

Purity:95.0%

Storage:Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping:Shipping with dry ice.

Description:Briakinumab (ABT-874) is a fully human anti-IL-12/23p40 monoclonal antibody. Briakinumab targets and neutralizes IL-12 and IL-23. Briakinumab can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.

In Vitro:Briakinumab targets the p40 molecule shared by interleukin-12 and interleukin-23[2].

IC50 & Target:IL-12 IL-23

Species:Human

Isotype:Human IgG1 lambda1

Recommend Isotype Controls:Human IgG1 lambda1, Isotype Control

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References:

[1]. Panaccione R, et, al. Briakinumab for treatment of Crohn's disease: results of a randomized trial. Inflamm Bowel Dis. 2015 Jun;21(6):1329-40.  [Content Brief]

[2]. Reich K, et, al. A 52-week trial comparing briakinumab with methotrexate in patients with psoriasis. N Engl J Med. 2011 Oct 27;365(17):1586-96.  [Content Brief]

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