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N-Acetyl-D-mannosamine

MCE China：N-Acetyl-D-mannosamine

Brand：MedChemExpress (MCE)

Cat. No.HY-128850

CAS：3615-17-6

Synonyms：N-Acetylmannosamine; ManNAc

Purity：98.0%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders.

In Vivo：N-Acetyl-D-mannosamine (administered orally in drinking water at a concentration of 1%, p.o., once daily for 16 weeks) can prevent obesity-induced hypertension in a high-fat diet-induced hypertensive mouse model by increasing the sialylation level of IgG glycans[3]. N-Acetyl-D-mannosamine (administered orally in drinking water at a dose of 2 g/kg, 4-6 mL per day, for 12 weeks) can reverse the reduction in sialylation in the kidneys and muscles of a GNE myopathy C57BL/6J mouse model with the knock-in (Gne p.M712T) mutation[4]. N-Acetyl-D-mannosamine (administered orally in drinking water at a concentration of 0.5%, ad libitum, for 8 weeks) improves synaptic transmission and Long-Term Potentiation (LTP) in 6-month-old and 14-month-old SAMR1 mice[4]。

IC50 & Target：Human Endogenous Metabolite

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References：

[1]. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101.  [Content Brief]

[2]. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778.  [Content Brief]

[3]. Peng J, et al. Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Circulation. 2019 Dec 10;140(24):2005-2018.  [Content Brief]

[4]. Niethamer TK, et al. Oral monosaccharide therapies to reverse renal and muscle hyposialylation in a mouse model of GNE myopathy. Mol Genet Metab. 2012 Dec;107(4):748-55.  [Content Brief]

[5]. Taniguchi S, et al. Chronic administration of N-acetyl-D-mannosamine improves age-associated impairment of long-term potentiation in the senescence-accelerated mouse. Neurosci Lett. 2015 Jun 26;598:41-6.  [Content Brief]