MedChemExpress - Model 8-Hydroxyguanosine -3868-31-3
8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimer’s disease and Down’s syndrome[1][2][3][4].MCE products for research use only. We do not sell to patients.
8-Hydroxyguanosine
MCE China：8-Hydroxyguanosine
Brand：MedChemExpress (MCE)
Cat. No.HY-113262
CAS：3868-31-3
Purity：99.91%
Storage：Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimer’s disease and Down’s syndrome.
In Vitro：8-Hydroxyguanosine (0.25 or 1.0 mM, 3 days) stimulates polyclonal immunoglobulin secretion and in the presence of antigen enhances the magnitude of the anti-TNP plaque-forming-cell antibody response to TNP-Ficoll [3].
In Vivo：8-Hydroxyguanosine (60 mg/kg, i.p., 4 h before LPS (1 mg/kg) injected) attenuates the LPS-induced increase in serum levels of TNF-α and IL-18 in LPS-treated mice[4].
IC50 & Target：Human Endogenous Metabolite
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References：
[1]. Fiala ES, et al. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res. 1989 Oct 15;49(20):5518-22. [Content Brief]
[2]. Abe T, et al. Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50. [Content Brief]
[3]. Ahmad A, et al. 8-Hydroxyguanosine and 8-methoxyguanosine possess immunostimulating activity for B lymphocytes. Cell Immunol. 1985 Aug;94(1):276-80. [Content Brief]
[4]. Choi S, et al. Anti-inflammatory effects of 8-hydroxy-2'-deoxyguanosine on lipopolysaccharide-induced inflammation via Rac suppression in Balb/c mice. Free Radic Biol Med. 2007 Dec 15;43(12):1594-603. [Content Brief]
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