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MedChemExpress - Model Linarin -480-36-4
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer[1][2][3][4].MCE products for research use only. We do not sell to patients.
Linarin
MCE China：Linarin
Brand：MedChemExpress (MCE)
Cat. No.HY-N0528
CAS：480-36-4
Synonyms：Buddleoside; Linarine
Purity：98.0%
Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer.
In Vitro：Linarin (25-100 μM; 24-72 h) inhibits the growth of human prostate cancer cells (LNCaP and DU145) and induces apoptosis[1]. Linarin (0.1-10 μM; 6-21 days) activates the BMP-2/RUNX2 pathway through PKA signal transduction, and then induces osteogenic differentiation and mineralization of MC3T3-E1 osteoblasts[2].
In Vivo：Linarin (oral administration; 50-150 mg/kg; 8 weeks) can improve bone loss in ovariectomized mice[2].
IC50 & Target：AChE
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References：
[1]. Singh RP, et al. Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis. 2005 Apr;26(4):845-54. [Content Brief]
[2]. Li J, et al. Linarin promotes osteogenic differentiation by activating the BMP-2/RUNX2 pathway via protein kinase A signaling. Int J Mol Med. 2016 Apr;37(4):901-10. [Content Brief]
[3]. Päivi P. Oinonen,etc. Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis, Fitoterapia,Volume 77, Issue 6, 2006, Pages 429-434, ISSN 0367-326X [Content Brief]
[4]. Mottaghipisheh J, et al. Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review. Pharmaceuticals (Basel). 2021 Oct 29;14(11):1104. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。