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Pinostrobin

MCE China：Pinostrobin

Brand：MedChemExpress (MCE)

Cat. No.HY-N2127

CAS：480-37-5

Purity：99.98%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases.

In Vitro：Pinostrobin (0-100 μg/mL, 72 h) inhibits HSV-1 virus, with the EC50 value of 22.71 μg/mL[2]. Pinostrobin (25-200 μM, 3 days) promotes melanin production in B16F10 cells by stimulating the expression of related melanin production regulatory factors in cAMP/PKA and p38 MAPK signaling pathways, and is non-toxic to cells[5]。 Pinostrobin (130 and 150 μM, 48 h) induces acute leukemia cell NB4 and MOLT-4 apoptosis via the regulation of miR-410-5p and SFRP5[6]. Pinostrobin (0-200 μM, 24-96 h) effectively induces apoptosis through ROS-mediated mitochondrial damage of cervical cancer cells (HeLa, Ca Ski, SiHa), and is not toxic to non-cancer cells HEK293 [7].

In Vivo：Pinostrobin (20 mg/kg , 50 mg/kg, i.g., daily for 7 days) delays the progression of lesions in a dose-dependent HSV-1 infected mouse model[2]. Pinostrobin (Single oral 10 and 20 mg/kg) has an anti-inflammatory effect by inhibiting TNF-α and IL-1β levels in rat models of LPS-induced inflammation [3]. Pinostrobin (daily oral 30 and 60 mg/kg for 2 months) has liver protective effect on liver cirrhosis induced by Thioacetamide (TAA) (HY-Y0698) in rats[4]. Relevant pharmacokinetic parameters of Pinostrobin in rats.[8] Route Dose (mg/kg) AUC0-t (ng·min/mL) MRT (h) Cmax (ng/mL) Tmax (h) t1/2 (min) i.g. 0.5 3817.80 6.26 615.35 4 4.34

IC50 & Target：HSV-1 TNF-α IL-1β PCSK9

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References：

[1]. Gao WY, et al. Pinostrobin Inhibits Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) Gene Expression through the Modulation of FoxO3a Protein in HepG2 Cells.J Agric Food Chem. 2018 Jun 20;66(24):6083-6093.  [Content Brief]

[2]. Wu N, et al. Activity investigation of pinostrobin towards herpes simplex virus-1 as determined by atomic force microscopy. Phytomedicine. 2011 Jan 15;18(2-3):110-8.

[3]. Patel NK, et al. Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1β production: in vitro and in vivo experimentation. Phytomedicine. 2014 Jun 15;21(7):946-53.  [Content Brief]

[4]. Shareef SH, et al. Hepatoprotective effect of pinostrobin against thioacetamide-induced liver cirrhosis in rats. Saudi J Biol Sci. 2023 Jan;30(1):103506.  [Content Brief]

[5]. Yoon JH, et al. Discovery of Pinostrobin as a Melanogenic Agent in cAMP/PKA and p38 MAPK Signaling Pathway. Nutrients. 2022 Sep 9;14(18):3713.  [Content Brief]

[6]. Norkaew C, et al. Pinostrobin induces acute leukemia cell apoptosis via the regulation of miR-410-5p and SFRP5. Life Sci. 2023 Jul 15;325:121739.  [Content Brief]

[7]. Jaudan A, et al. Induction of apoptosis by pinostrobin in human cervical cancer cells: Possible mechanism of action. PLoS One. 2018 Feb 8;13(2):e0191523.  [Content Brief]

[8]. Hua X, et al. Determination of pinostrobin in rat plasma by LC-MS/MS: application to pharmacokinetics. J Pharm Biomed Anal. 2011 Dec 5;56(4):841-5.  [Content Brief]